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” What to do when i am exposed to a varicella (chicken pox)during the infective period?". One topic debated much today was about the efficiency of acyclovir as a chemoprophylactic agent in immunocompetent persons. All of us know there is a effective, safe time tested vaccine against varicella.Only problem with this is the cost, Need two doses and cost two thousand rupees for a dose . So even though this is relevant for prevention, a country like ours can not afford. Ideally all of us should get immunized against ie primary prvention. In that case the above question does nt occur. still there is answer to the above question Vaccination even after exposure (post exposure vaccination ) is effective in varicella.This is possible because the incubation period of this illness is long enough ie two to three weeks. If we give vaccine early after contact protecive level of immunity can be raised before the actual virus produce the illness. So the illness may not occur at all or occur